Yes. Tradogram is designed to handle both standardized inventory and unique, "one-off" purchases. You are not required to have an item pre-saved in your database to include it in a Requisition, Purchase Order, or RFQ.
If you need to request an item that does not yet exist in your Item Database, follow these steps during the transaction creation process:

If you find yourself manually entering the same "external" item frequently, you can save time by adding it to your permanent Item Database.
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